Unlike other forms of hand rejuvenation, the Radiesse hand lift does not require any sort of anesthesia. A Radiesse specialist will inject units of Radiesse into parts of your hand. The injections should take between ten and fifteen minutes. The injections will be slightly painful, and may result in minor swelling, redness, and bruising at the site of the injection. Afterwards, it’s recommended that you rest your hands for the next day or so as to not increase swelling.