The mechanism of injury is a natural process, which makes Dermapen a holistic approach to skin therapy. Four major phases of physiological wound response help in stimulating new healthy tissue growth.
First, an inflammatory response (1-3 days), to the initial injury promotes the chemotaxis response and proliferation of fibroblasts. The body’s platelets also respond to initiate a wound matrix. This response is the early phase of cell migration to remove debris and bacteria and stimulate the next proliferative phase.
During the second phase (3-5 days), the new fibroblasts, monocytes, keratinocytes of the first phase continue to proliferate and multiply. New collagen will be laid down and deposited with new tissue formation. Next a fibrotic response (5-20 days), of growth factors are released and fibroblasts release collagen. Finally, the maturation stage of new healthy skin takes place from day 28 to two years after needling. Collagens mature and stiffen and the matrix of new tissue shows 80% to full tensile strength.